|LETTER TO THE EDITOR
|Year : 2016 | Volume
| Issue : 3 | Page : 112
Gangrene and Malaria
Khichar Purnaram Shubhakaran
Department of Neurology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
|Date of Web Publication||25-Jul-2016|
Dr. Khichar Purnaram Shubhakaran
Department of Neurology, Dr. S. N. Medical College, Jodhpur, Rajasthan
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Shubhakaran KP. Gangrene and Malaria. Indian J Vasc Endovasc Surg 2016;3:112
I read an interesting case report of Plasmodium vivax malaria complicated by symmetrical peripheral gangrene. With the reemergence of malaria, such rare but unique complications of malaria have been observed from time to time and reported mainly from India.,,, More frequently being described in falciparum malaria, however, a few such cases or complications are also reported in P. vivax and mixed  malaria also. Exact pathogenesis could not be ascertained. Microcirculatory block due to sludging of the parasitized erythrocytes in capillaries is a well-known factor in heavy Plasmodium falciparum parasitemia. The blockage of terminal arteries/arterioles could be the important reason for the gangrene. The vascular flow in the organs is disturbed by vascular collapse, thrombosis, infarction, and similar effects brought about by clumping together of parasitized cells. All these factors slow down the circulation and cause “sludging.” In a patient presenting with dry gangrene and fever, a possibility of malaria must be kept in mind not only in endemic areas but also in nonendemic areas because of the resurgence of malaria in the last few years.
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