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Year : 2016  |  Volume : 3  |  Issue : 3  |  Page : 112

Gangrene and Malaria

Department of Neurology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India

Date of Web Publication25-Jul-2016

Correspondence Address:
Dr. Khichar Purnaram Shubhakaran
Department of Neurology, Dr. S. N. Medical College, Jodhpur, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-0820.186718

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How to cite this article:
Shubhakaran KP. Gangrene and Malaria. Indian J Vasc Endovasc Surg 2016;3:112

How to cite this URL:
Shubhakaran KP. Gangrene and Malaria. Indian J Vasc Endovasc Surg [serial online] 2016 [cited 2022 Nov 28];3:112. Available from:

I read an interesting case report of Plasmodium vivax malaria complicated by symmetrical peripheral gangrene.[1] With the reemergence of malaria, such rare but unique complications of malaria have been observed from time to time and reported mainly from India.[2],[3],[4],[5] More frequently being described in falciparum malaria, however, a few such cases or complications are also reported in P. vivax[4] and mixed [5] malaria also. Exact pathogenesis could not be ascertained.[2] Microcirculatory block due to sludging of the parasitized erythrocytes in capillaries is a well-known factor in heavy Plasmodium falciparum parasitemia. The blockage of terminal arteries/arterioles could be the important reason for the gangrene. The vascular flow in the organs is disturbed by vascular collapse, thrombosis, infarction, and similar effects brought about by clumping together of parasitized cells. All these factors slow down the circulation and cause “sludging.” In a patient presenting with dry gangrene and fever, a possibility of malaria must be kept in mind not only in endemic areas but also in nonendemic areas because of the resurgence of malaria in the last few years.[2]

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  References Top

Chatterjee K, Sen C. Symmetrical peripheral gangrene complicating vivax malaria. Indian J Vasc Endovasc Surg 2015;2:166-7.  Back to cited text no. 1
  Medknow Journal  
Kochar Shubhakaran DK, Kumawat B, Kochar SK. A patient with falciparum malaria and bilateral gangrene of the feet who developed arrhythmia/ventricular fibrillation after quinine therapy. QJM 1998;91:246.  Back to cited text no. 2
Arya TV, Singh SP, Singh DK. Bilateral foot gangrene occurring in falciparum malaria. JAPI 1990;38:30.  Back to cited text no. 3
Arora N, Gogna A, Kumar D, Puri K. Peripheral gangrene in Plasmodium vivax malaria: A rare manifestation. Trop Doct 2013;43:23-4.  Back to cited text no. 4
Agrawal A, Rastogi A, Tiwari D. Symmetric peripheral gangrene with mixed malaria. Indian J Pediatr 2007;74:587-8.  Back to cited text no. 5


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