ORIGINAL ARTICLE
Year : 2020  |  Volume : 7  |  Issue : 4  |  Page : 415-419

Assessment of risk factors in established cases of venous thrombosis


Department of General Surgery, Southern Railway Head Quarters Hospital, Chennai, Tamil Nadu, Ex-Pfizer Ltd., Mumbai, Maharashtra, India

Correspondence Address:
R Chithra Barvadheesh
Department of General Surgery, Southern Railway Head Quarters Hospital, Chennai, Tamil Nadu, Ex-Pfizer Ltd., Mumbai, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijves.ijves_56_20

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Background: Despite prevalence of venous thrombosis (VT) in Indians, there are few prospective studies. Objective: To analyze the demographic profile, proven risk factors, and coagulation profile of south Indian patients with proven VT. Materials and Methods: This single-center prospective observational study was conducted among patients with proven VT from August 2013 to July 2019. Hypercoagulable workup (serum homocysteine, activity of protein C, protein S and anti-thrombin III, antiphospholipid antibodies immunoglobulin [IgM] and IgG, factor V [Leiden] mutation) was performed. Results: Out of 295 patients (mean age 56 years; male 64%) of VT, 85.76% had deep vein thrombosis (DVT) whereas 14.24% had superficial vein thrombosis (SVT). Patients with DVT were significantly older than those with SVT (P < 0.05). DVT was most common in the femoropopliteal segment 132 (52.17%), followed by the iliofemoral segment 78 (30.83%). Unprovoked primary cases (58%) were common. A total of 123 (41.69%) patients had identifiable provoking risk factors, of which malignancy 30 (24.39%) and postsurgery status 29 (23.58%) were the most common causes. A total of 101 (34.47%) patients were tested for coagulation abnormalities of whom 14 (13.86%) had normal profiles. Hyperhomocysteinemia was the commonest coagulation anomaly 59 (58.41%). Factor V (Leiden) mutation tested in 48 (16.27%) patients of which six (12.5%) were positive. Conclusions: Study population of VT revealed male predominance. Immobilization due to either medical or surgical causes, emerged as a major risk factor. The most common modifiable factor is postoperative care and the common coagulation anomaly is hyperhomocysteinemia.


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